For example, some immunoproteasome-related proteins (Proteasome subunit beta type-1, Proteasome subunit alpha type-3, Proteasome subunit beta type-4, Proteasome subunit alpha type-1) which have been reported to be crucial for inflammatory T helper lymphocyte differentiation and implicated in autoimmune disease pathogenesis [54, 55]. The gene discussed is PSMB4; the disease is autoimmune disease.