The results showed that both TAK-242 and PDTC significantly inhibited the mRNA expression level of TLR-4 and NF-κB p65, reduced production of pro-inflammatory cytokines (IL-1β and IL-6) and increased secretion of anti-inflammatory cytokine (TGF-β) in infected mice, subsequently alleviated intestinal inflammation and impeded larval intrusion of gut mucosa. The gene discussed is TLR4; the disease is inflammation.