For example, TRIP13 plays an oncogenic role in glioblastoma via the FBXW7/c-MYC pathway [18] and induces hepatocellular carcinoma (HCC) cell migration, invasion, and metastasis through AKT/mTOR signaling via and interaction with ACTN4 [19]. The gene discussed is FBXW7; the disease is hepatocellular carcinoma.