In a study by Gherbon and colleagues involving 122 Romanians with T1DM; 80 on MDI and 22 on insulin pump; those on MDI showed significant worsening of their blood glucose levels during the Covid-19 pandemic in comparison to those on insulin pump who showed improvement of their blood glucose levels which they attributed to delayed administration of insulin and inadequate insulin dosing by those on the MDI. This evidence concerns the gene INS and type 1 diabetes mellitus.