BRD4 and head and neck squamous cell carcinoma: Jing et al. found that under epigenetic regulation of BRD4, JOSD1 was overexpressed in HNSCC, and increased expression of JOSD1 was positively correlated with proliferation and chemoresistance of HNSCC cells, while highly expressed JOSD1 was also associated with poor prognosis of HNSCC patients [42].