In association with tumor and microenvironmental cells, HIF-1 induces angiogenesis via HIF-1-dependent expression of VEGFA and platelet-derived growth factor B, aids cancer cell survival by mediating extracellular matrix remodeling and metabolic reprogramming in cancer-associated fibroblasts, and suppresses adaptive immune system via Treg and TAM recruitment and activation [43]. The gene discussed is VEGFA; the disease is cancer.