Re-analysis of CES data with an in-silico gene list consisting of the entire panel of genes associated with monogenic liver disease (289 genes), allowed for the identification of a splicing variant [chr1:120459322-A-T; c.6028-5T > A] in NOTCH2 gene (#600,275), which is associated with Alagille syndrome (https://omim.org/entry/610205). Here, NOTCH2 is linked to Alagille syndrome.