The top 10 significantly altered pathways were as follows: complement and coagulation cascades (ko04610); staphylococcus aureus infection (ko05150); protein digestion and absorption (ko04974); cholesterol metabolism (ko04979); rheumatoid arthritis (ko05323); mineral absorption (ko04978); cytokine-cytokine receptor interaction (ko04060); neuroactive ligand-receptor interaction (ko04080); IL-17 signaling pathway (ko04657); systemic lupus erythematosus (ko05322). This evidence concerns the gene IL17A and rheumatoid arthritis.