TP53 and hepatocellular carcinoma: For instance, hepatocellular carcinoma patients in the high cuprotosis-related risk score had a high mutational frequency of some tumor suppressors such as tumor protein P53 (TP53) and Breast-cancer susceptibility gene 1 (BRCA1)-associated protein 1 (BAP1) and a low frequency of catenin beta 1 (CTNNB1) [9].