In vascular smooth muscle cell (VSMC) dysfunction mediated by type 2 diabetes conditions, studies have shown that metformin restores TET2 by inhibiting the expression of YTHDC2 and circYTHDC2, thereby preventing the progression of VSMC dysfunction under high glucose conditions (Yuan et al. 2021). The gene discussed is YTHDC2; the disease is type 2 diabetes mellitus.