In transcriptional subtyping studies of pancreatic ductal adenocarcinoma, TET2-driven 5-hmC signature of GATA6 was confirmed, and the use of metformin can enhance TET2 stability and subsequently restore 5-hmC and GATA6 levels, restoring the squamoid tumor phenotype and Wnt dependence in vitro and in vivo (Eyres et al. 2021). Here, GATA6 is linked to pancreatic ductal adenocarcinoma.