Another type of SCAR found by Calandra and co-workers includes two novel AFG3L2 heterozygous mutations (W128* and R695G) that cause spastic ataxia with unique eye-of-the-tiger pattern that can be related to iron deposition and pantothenate kinase-related neurodegeneration that affects CoA synthesis pathway [18]. Here, AFG3L2 is linked to Scarring.