Because of all these characteristics, certain antioxidants and oxidative compounds such as Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), paraoxonase 1 (PON1) ferric reducing ability of plasma (FRAP) and total serum thiol concentrations have been studied to evaluate the antioxidant response and oxidative damage in dogs with IBD (Rubio et al. 2016a, b a, b; Segarra et al. 2016; Rubio et al. 2017). The gene discussed is PON1; the disease is inflammatory bowel disease.