NLRP3 and COVID-19: SARS-CoV-2 can directly or indirectly affect the sensor nucleotide-binding oligomerization structural domain, leucine-rich repeat sequence, and NLRP3 of inflammasomes, ultimately leading to the assembly of NLRP3 inflammasome and the activation of inflammatory caspases, thereby inducing an inflammatory disruption of severe COVID-19 (Jung and Lee 2022).