NLRP3 and depressive disorder: Furthermore, an increase in levels of NLRP3 correlated with depressive-like behaviors in lipopolysaccharide (LPS), restraint stress, and ovariectomized (OVX)-induced depression models (Xia et al. 2023; Iwata et al. 2016; Alcocer-Gómez et al. 2014, 2017).