IL1B and major depressive disorder: Ginsenoside Rg1 treatment for 3 weeks attenuated depression-related behaviors in chronic unpredictable mild stress (CUMS)-exposed rats, as evidenced by increased sucrose preference, improved locomotor activity, and shortened sedentary time, and these ameliorative effects of ginsenoside Rg1 treatment were associated with modulation of pro-inflammatory cytokine IL-1β (Zhang et al. 2019).