Specifically, these common pathways included neuroactive ligand-receptor interaction, serotonergic synapse, pathways in cancer, phosphoinositide-3-kinase/Akt (PI3K/Akt) signaling, mitogen-activated protein kinase (MAPK) signaling, pathways of neurodegeneration - multiple diseases, Alzheimer disease (AD), and vascular smooth muscle contraction. This evidence concerns the gene WNK2 and early-onset autosomal dominant Alzheimer disease.