Consistently, DEG analysis revealed that TFH-related genes, including CXCR5, CXCL13, IL21, and CD40LG, were significantly upregulated in chr5-gain tumor cells compared to those without and GSVA showed that the TFH signature enrichment was observed in total and LN tumor cells while being insignificant in PB tumor cells (Fig. 3B, Fig. S7B). Here, IL21 is linked to neoplasm.