LAMP3 and cancer: LAMP3+ cDCs were characterized by high immune regulatory gene expression, including CD274 (encoding PD-L1) and PDCD1LG2 (encoding PD-L2) [46], consistent with “mregDCs,” a subset of DCs co-expressing maturation and immunoregulatory genes identified in various cancers [43, 46] (Fig. S11B, C and F).