KIR3DL2 and neoplasm: While the roles of Leukocyte Immunoglobulin-Like Receptors (LILRs) and Killer cell Immunoglobulin-like Receptors (KIRs) were initially evolved to quell an overactive immune response, tumors have hijacked the response for immune evasion and T cell tolerance, allowing the tumor cells to grow unabated.