Among 49 downregulated proteins, 15 proteins (Centrosomal protein of 290 kDa, zinc finger BED domain-containing protein 1, polyadenylate-binding protein 1, centromere protein F, 40S ribosomal protein S8, defensin-5, leiomodin-3, glutaminyl-peptide cyclotransferase, beta-taxilin, secretoglobin family 3A member 1, ubiquitin-like-conjugating enzyme ATG10, zinc finger SWIM domain-containing protein 6, protein kinase C and casein kinase substrate in neurons protein 2, integral membrane protein 2B, and UHRF1-binding protein 1) have not been previously reported in direct association with T2DM. Here, DEFA5 is linked to type 2 diabetes mellitus.