IFNG and neoplasm: Moreover, although macrophage depletion tended to increase the proportion of CD8+ and IFN-γ + CD8 + T cells, the increase was not significant, and the depletion of macrophages partly removed the pladienolide B-induced increase of CD8+ and IFN-γ + CD8 + T cell proportion among tumor-infiltrating lymphocytes (Fig. 5d).