Moreover, HCAR2 is implicated in mitigating many pathophysiological processes, including the reduction of chemokine and pro-inflammatory cytokine production; amelioration of atherosclerosis, sepsis, and diabetic retinopathy; suppression of the occurrence of breast cancer, colitis, and acute pancreatitis; and maintenance of the integrity of the intestinal barrier5,9,10. Here, HCAR2 is linked to atherosclerosis.