AKT1 and polycystic ovary syndrome: To further understand the molecular signaling mechanisms underlying the functions of MIGA1 and -2 in follicular growth and development, this study investigated the effects of MIGA1 and -2 on GCs proliferation as well as on the Hippo/YAP1 and PI3K/AKT signaling pathways, to elucidate their involvement in the molecular pathogenesis of PCOS.