In addition to these mechanisms of acquired RyR2 channel dysregulation, missense and truncating mutations in the RyR2 gene have been linked to increased SR Ca2+ leak in transgenic mice carrying human-related RyR2 mutations, for example, R2474S (Lehnart et al, 2008) and P2328S (Lehnart et al, 2004) that mimic the phenotype of catecholaminergic polymorphic ventricular tachycardia (CPVT) (Wleklinski et al, 2020). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.