Increased catecholamine-induced acute SR Ca2+ leak has been extensively discussed for CPVT type 1 in which diastolic Ca2+ leak occurs via abnormally enhanced activity of mutant tetrameric RyR2 channels, promoting delayed afterdepolarizations, atrial and ventricular arrhythmias, and sudden cardiac death (Wleklinski et al, 2020). The gene discussed is RYR2; the disease is Ventricular arrhythmia.