RYR2 and catecholaminergic polymorphic ventricular tachycardia: Recently, the RyCal S36 corrected Ca2+ leak in human iPSC-derived cardiomyocytes from a patient with CPVT (RyR2-E4076K) by reducing RyR2-mediated Ca2+ spark activity and prohibited arrhythmia but not the progression of heart failure in mice.