RYR2 and catecholaminergic polymorphic ventricular tachycardia: In detail, ARM210 reversed the destabilization of the bridging solenoid domain (Hadiatullah et al, 2022) of RyR2 induced by the CPVT-associated RyR2–R2474S mutation thereby stabilizing the closed channel conformation (Miotto et al, 2022).