MAPT and Alzheimer disease: Furthermore, senktide treatment not only attenuated the abnormalities in MFBs (Fig. 6I, 6K, and 6L) but also rescued the pattern separation impairments (Fig. 6M and 6N), LTP inhibition (Fig. 6O and 6P), reduced mEPSC frequencies (Fig. 6Q–T) and tau hyperphosphorylation (Figs. 6U, 6V and S11K) in the MF-CA3 circuit in the AD mice.