Collectively, this perturbation in monocyte biology may explain the more pro‐inflammatory phenotype in SAs compared with WEs, with studies reporting higher CRP and IL‐6 concentrations in healthy middle‐aged SA men (Chambers et al., 2001), women (Peters et al., 2013), and men with central obesity (Roberts et al., 2023). This evidence concerns the gene IL6 and Abdominal obesity.