Importantly, CD8+ T cells and tumor-specific MHC-I played a crucial role in the tumor control mediated by Pikfyve-depletion, as depletion of CD8+ T cells by anti-CD8 antibody or disruption of MHC-I by B2m-knockout rescued progression of the tumors derived from Pikfyve-null cancer cells. Here, B2M is linked to neoplasm.