RIPK3 and Zika virus infectious disease: We and others also previously showed that RIPK3 activation in cortical neurons following ZIKV infection leads to interferon regulatory factor 1 (IRF1) activation, which was required for expression of at least a subset of RIPK3-induced genes in that setting, although this effect is likely indirect, as IRF1 is not a known RIPK3 substrate [17].