The top 10 ICB response pathways that CoCuLncSig correlated with were progesterone mediated oocyte maturation, oocyte meiosis, cell cycle, p53 signaling pathway, viral carcinogenesis, pyrimidine metabolism, mismatch repair, Fanconi anemia pathway, homologous recombination, and spliceosome (Figure 7A, Supplementary Table 5). The gene discussed is TP53; the disease is Fanconi anemia.