SNCA and synucleinopathy: Interestingly, alpha-synuclein, a principal component of Lewy bodies in synucleinopathies and detected both surrounding and inside mitochondria [78,79], can stimulate an increased translocation of Drp1 (a mammalian Dnm1 homolog [80]) to the mitochondria [81,82] with ensuing mitochondrial fragmentation [83].