MADD, which was associated with Sensory hearing loss and has an expression pattern resembling that of Myo7a (S4 Fig and S3 Table), is an activator of the Rab3 small GTP-binding protein family, and has been shown to be critical for neurotransmitter release in neuromuscular junctions and in hippocampal neurons [38,39]; it also may play a role in inner ear synapses but that has yet to be determined. This evidence concerns the gene MYO7A and hearing loss disorder.