PRDM9 and cancer: Although its precise role in cancer is still being elucidated, emerging evidence suggests that KMT2E may play a role in cell cycle regulation and tumor progression.[66] Notably, SMYD3, which accumulated in clone 2, is a histone methyltransferase that contributes to the regulation of gene expression through histone methylation.[67] It has been shown to promote tumor growth and metastasis by altering gene expression patterns and affecting signaling pathways involved in cell proliferation and invasion.