Although its precise role in cancer is still being elucidated, emerging evidence suggests that KMT2E may play a role in cell cycle regulation and tumor progression.[66] Notably, SMYD3, which accumulated in clone 2, is a histone methyltransferase that contributes to the regulation of gene expression through histone methylation.[67] It has been shown to promote tumor growth and metastasis by altering gene expression patterns and affecting signaling pathways involved in cell proliferation and invasion. This evidence concerns the gene PRDM9 and neoplasm.