C2 and C5 mainly resided in breast tumors and expressed tumor suppressor genes (EXT1[28] and HPSE2[29]), which may regulate the heparan sulfate in the breast TME; C13 mainly resided in breast NAT and highly expressed LRP1B,[30] a putative tumor suppressor that may inhibit cancer migration and invasion. The gene discussed is LRP1B; the disease is breast neoplasm.