Another matrix CAF subcluster, C11, was linked to angiogenesis and highly expressed NOTCH3 (an important receptor in vascularization and angiogenesis), COL18A1 (involved in angiogenesis regulation), COL4A1, and COL4A2,[27] which might promote the proliferation and metastasis of tumor. This evidence concerns the gene NOTCH3 and neoplasm.