Additionally, upregulated CSC transcripts were identified, such as the transcript of ETV4 (Figure 4h),[53] SERPINE2, MALAT1,[54] and pre‐mRNA of ANLN (Figure S9c, Supporting Information).[55] Known snRNAs are closely related to the splicing process, and specific isoforms have been reported in many cancers.[56, 57] Taken together, we believe that the mutations in snRNAs may directly affect the splicing in malignant cells and promote the expression of certain CSC gene marker isoforms. This evidence concerns the gene ETV4 and cancer.