Targeted at intestinal microbiota dysbiosis, FMT has proven potential in the treatment of Clostridium difficile infections and other disorders, such as irritable bowel syndrome.56,57 Several studies have reported the benefits of FMT in animal models of PD.58,59 In line with these finding, our study found FMT significantly improved the balance ability, motor coordination, muscle strength, and obviously shorten the defecation time of E. coli-treated Lrrk2 R1628P mice by restoring the balance of the intestinal microbiota composition. Here, LRRK2 is linked to Parkinson disease.