Axin1 might be more than a mere gatekeeper in the Wnt/β-catenin pathway.11 A study utilizing RNA-seq has unveiled that Axin1 is linked to IFN-γ/STAT1/Th1 immune program through an unidentified mechanism; moreover, CRC patients exhibiting an Axin1-dependent gene expression signature tend to have a more favorable prognosis.4 Guo et al. propose that Axin1 enhances the antiviral response to influenza by activating the JNK/c-Jun and Smad3 pathways, reducing virus replication, and increasing interferon (IFN) production. Here, AXIN1 is linked to colorectal carcinoma.