Based on the literature, we found genes such IL-6, RIPK2, PLA2G3, CCL11, ICAM1, and NLRP3, which are associated with specific bacterial species present in IBD patients, suggesting that these species are the most susceptible to the activity of these genes.37 Further analysis revealed that at least four taxons of IBD patients overlapped with those of Cldn3KO mice. The gene discussed is ICAM1; the disease is inflammatory bowel disease.