CLDN3 and colitis: Therefore, we further examined if Cldn3 deficient mice were also susceptible to C. rodentium colitis, which is commonly used to model IBD.10 Similar to DSS-colitis, when subjected to C. rodentium colitis (for 14 days), significantly altered body weight (% change) and colonic thickness were observed in Cldn3KO mice compared to WT mice (Figure 2k, l).