We next investigated transcriptional profiles within the MΦ clusters isolated from aGvHD skin and detected high expression of genes described in skin-resident, anti-inflammatory, tissue-remodelling and tumour-associated MΦ, including MRC1 (encoding CD206), C1QC and CD163 (Figure 3b).25,26 Healthy skin MΦs displayed a similar transcriptome with low expression of pro-­inflammatory genes and migration marker CCR7 [Figure S4a (see Supporting Information)]. This evidence concerns the gene CD163 and neoplasm.