These results support previous studies suggesting that microglial activation plays an important role in the development of psychiatric symptoms such as mania, depression, psychosis, and anxiety in a range of psychiatric disorders.33,34 Recent studies have linked Aβ and tau with NPSs across the AD spectrum,6,7,35 and we also found a direct association between Aβ or tau with NPS. Here, MAPT is linked to depressive disorder.