MAPT and major depressive disorder: This network is disrupted in patients with AD.39,40,41 Dysfunction in the DMN is associated with early accumulation of Aβ in the brain and with the appearance of agitation, depression, and anxiety.42,43 In addition, microglial activation in the inferior temporal, fusiform, and entorhinal cortices (key regions for tau accumulation in early Braak stages) is associated with NPS.