As ovarian cancer cells behave differently as spheroids than when cultured in adherent conditions, not only phenotypically but also at the molecular level (Fig. 4B and Fig. S3A), the expression of some epithelial‐to‐mesenchymal transition (EMT) markers was characterized in sh‐CTRL and sh‐PDGFRB spheroids (3D) and compared to those of adherent cells (2D). The gene discussed is PDGFRB; the disease is ovarian cancer.