Interestingly, fibronectin was observed to change the distribution presented in 3D cultured CAFs (Fig. 5D) and to be specifically localized at the limiting area between central CAFs and peripheral sh‐PDGFRB cells within the chimeric spheroids (Fig. 5E), which is indicative of its role in ovarian cancer cells adhesion. The gene discussed is FN1; the disease is ovarian cancer.