RRM2B and colorectal carcinoma: Conversely, gain of 8q could play a role in CRC, since this region harbors genes which are altered in CRC (e.g. UBR5, KLF10, EIF3H) or which are associated with the metastatic process (e.g. RRM2B, NOV, RAD21) (Muñoz-Bellvis et al. 2012).