For instance, the faithful mimicking of cystic fibrosis‐related diabetes was achieved by generating organoids from isolated pancreatic ductal epithelial cells (PDECs) in the MPS.[166] Additionally, a pancreas‐on‐a‐chip enabled the assessment of organ‐specific functions, revealing a 54% reduction in insulin secretion by islet cells due to attenuated CFTR function in PDECs (Figure 4C).[139] These applications highlight the significant contribution of MPS in replicating and investigating in vivo phenomena within controlled laboratory settings. Here, CFTR is linked to cystic fibrosis.