Similarly, hyperactivation of mTORC1 signaling as a result of aberrant Akt signaling seems to occur early in AD development (Tramutola et al., 2015), leading to greater IRS‐1 serine residue phosphorylation (Copps & White, 2012), further impairing insulin signaling (Zhang et al., 2008). Here, IRS1 is linked to Alzheimer disease.