As it pertains to the brain, important observations by researchers such as Talbot et al. (2012) have shown that a reduction of insulin receptor content alongside greater inhibitory phosphorylation of IRS‐1 S636 is evident with both IR and AD post‐mortem brains (Moloney et al., 2010; Tramutola et al., 2015, 2020), pointing to other major markers in insulin signaling that are impacted with IR. This evidence concerns the gene IRS1 and Alzheimer disease.