Peripherally, reductions in insulin receptor content, hyper‐phosphorylation of inhibitory IRS‐1 serine sites, blunted Akt phosphorylation, and overactive mTORC1 are common impairments observed with T2D and IR (Merz & Thurmond, 2020; Vlavcheski et al., 2020). The gene discussed is IRS1; the disease is type 2 diabetes mellitus.