The IMRAS whole-blood transcriptomic studies revealed that the protection status was associated with different timing, magnitude, and nature of NK cell-related genes early after immunization.25 The role of NK cells in malaria immunity, specifically in the antibody-mediated immunity,50,51 has been recently spotlighted in Kenya and Uganda,52,53 showing a potential link between the maintenance of a subset of natural killer cells (CD56 negative) and the successful control of malaria infection.53 This evidence concerns the gene NCAM1 and malaria.