C5 and aspergillosis: Similar C5-complement-deficient mouse strains including DBA/2 and S/J mice have been used in disseminated models of aspergillosis with robust brain burden; however, to our knowledge, these models have primarily been used for antifungal efficacy studies and have not been validated for or employed to elucidate the mechanism of fungal dissemination and growth in the brain (12, 26, 27).