While concordant to a large degree, we speculate that observed differences between LMP1 effects on Akata vs BL-41 host gene expression may likely reflect the somewhat higher basal NF-κB levels observed in BL-41, and perhaps also differences in driver mutation pathways frequently found in EBV+ vs EBV− Burkitt lymphomas (69, 70). Here, NFKB1 is linked to Burkitt lymphoma.