ITGB3 and medulloblastoma: To investigate the role of αvβ3 in medulloblastoma tumorigenesis, ITGB3 was knocked out (KO) in DAOY cells using CRISPR/Cas9 technology, and β3 was overexpressed in DAOY-KO and HD-MB03 cells (Fig. 1D and E; Supplementary Fig. S1).