Cox5a is a subunit of cytochrome c oxidase (complex IV), which is essential in the assembly and regulation of mitochondrial respiratory chain holoenzyme.[33, 34] The activity of mitochondrial complex IV was dramatically decreased in Alzheimer's disease as an early alteration of brain bioenergetic dysfunction.[35, 36] We detected increased Cox5a after 5 days of salicylate treatment in tinnitus mice, indicating that Cox5a may serve as an early‐stage index to reflex ATP generation and neural activity in ACC. The gene discussed is COX5A; the disease is early-onset autosomal dominant Alzheimer disease.