RIPK3 and Thrombocytopenia: Notably, although anemia in Abin1Q478H/Q478H mice was ameliorated by Ripk3 deficiency, the Abin1Q478H/Q478HRipk3–/–, Abin1Q478H/Q478HRipk1K45A/K45A, and Abin1Q478H/Q478HMlkl–/– mice still showed severe thrombocytopenia, similar to the Abin1Q478H/Q478H mice (Figure S3e,f, Supporting Information).