Furthermore, Abin1Q478H/Q478H mice exhibited signs of extramedullary hematopoiesis and BMF in the middle and late stages, although only a small proportion of patients with MDSs may experience these symptoms.[8, 14] The deletion of Ripk3 caused alleviation of the anemia symptoms in Abin1Q478H/Q478H mice through necroptosis‐independent mechanisms. This evidence concerns the gene RIPK3 and anemia (phenotype).