Having established that MORC3 has a repressive effect on the MIEP driving GFP in stably transduced THP1 cells and that MORC3 is upregulated during latency in both THP1 cells and primary monocytes, we next investigated whether MORC3 also plays a repressive role on the MIEP in the context of a latent infection. The gene discussed is MORC3; the disease is disease arising from reactivation of latent virus.