For instance, during lytic infection, HSV‐1, Kaposi's Sarcoma Herpes Virus (KSHV) and Epstein Barr Virus directly degrade PML via viral proteins such as ICP0, ORF75 and BNRF1,47, 48, 49 respectively, though there is no evidence that PML NBs are disrupted by these viruses during latent infection. The gene discussed is PML; the disease is disease arising from reactivation of latent virus.