ATG5 and cancer: As autophagy not only exerts direct effects via protein degradation but also regulates the transcriptional and epigenetic programs in cells, including ECs (Maes et al, 2014; Di Malta et al, 2019; Meçe et al, 2022), we initially conducted transcriptional profiling of FACs‐sorted ATG5‐proficent and ‐deficient CD45−Ter119−CD31+ TECs from B16‐F10 tumors (yielding more than 90% pure TECs) (Fig EV3A), with a panel of 770 genes implicated in cancer immunomodulation using the Nanostring technology (Fig 3A).