To uncover the contribution of EC‐autophagy in regulating immunosurveillance in melanoma, we crossed the inducible PDGFb‐creERT2Rosa26tdTomato/tdTomatoline with Atg5fl/fl mice to delete the essential autophagy gene Atg5 from blood ECs (i.e., Atg5BECKO) upon tamoxifen administration. This evidence concerns the gene ATG5 and melanoma.