AQP1 and neoplasm: CD31/AQP1 double‐positive (identifying huTECs), CD8+ PD1− GrzB− T‐cells (identifying naïve CD8+ T‐cells) and CD8+ PD1+ GrzB+ (identifying activated/effector CD8+ T‐cells) (Sade‐Feldman et al, 2018) were evaluated in three distinct spatial compartments of the biopsy, namely the “tumoral bulk,” the tumor–stroma interface, and the nontumoral areas.