These cells bind antigens trapped in the luminal mucus and deliver them to lymphocytes in GALT for immune surveillance.[194] Lineage tracing has shown that receptor activator of nuclear factor kappa‐B ligand (RANKL), which is produced by follicle‐associated epithelium, is crucial for differentiation of M cells.[195] Indeed, treatment with exogenous RANKL enriches for M cells, and identified an expression profile that was previously impossible to capture.[196] Tuft cells are another rare cell type important for launching type‐2 immune responses to parasitic infection by Helminths. Here, TNFSF11 is linked to parasitic infectious disease.