CD4 and neoplasm: Moreover, BG/OVA@EcN exhibited the strongest ability to promote tumor infiltration of the activated IFN‐γ+CD8+ T (Figure 6g) and CD69+CD8+ T cells (Figure 6h), as well as the activated CD69+CD4+ T cells (Figure 6j), while decreasing the numbers of Tregs (Foxp3+CD25+CD4+CD3+CD45+ cells, Figure 6k).