For example, SIRT2 has been proposed to play a role in Alzheimer's disease and Parkinson's disease, two common pathologies which spontaneously occur with ageing, and are modelled in rodents using transgenic or chemical insults (de Oliveira et al., 2017; Esteves et al., 2018; Godena et al., 2014; Outeiro et al., 2007; Yan et al., 2022), leading to medicinal chemistry efforts to develop small molecule inhibitors against this protein (Hong et al., 2019; Nielsen et al., 2021; Outeiro et al., 2007). Here, SIRT2 is linked to early-onset autosomal dominant Alzheimer disease.