Isolated TERT promotor mutations are occasionally described in benign disease.31,62–64 Mostly known for their presence in nonsmall cell lung cancer, EGFR mutations are observed in PTC, too.65 To the best of our knowledge, the correlation between isolated CDKN2A or EGFR mutations and benign thyroid disease has infrequently been studied.66 Here, CDKN2A is linked to lung cancer.